The Haematology Research Unit, based at St George Hospital Kogarah, is dedicated to improving cardiovascular outcomes across New South Wales, Australia and globally. The team investigates the molecular mechanisms of blood coagulation and inflammation that drive thrombotic pathology in cardiovascular diseases, including coronary artery disease, stroke, deep vein thrombosis, and immune- or vaccine-induced thrombocytopenia.
To address these complex questions, we employ a multidisciplinary approach integrating biochemical assays, microfluidics, proteomics, flow cytometry and animal models. With an emphasis of translating basic science discoveries to clinical practice, the team has developed novel anti-thrombotic biomolecules, identified new biomarkers, and created novel diagnostic bioassays. In collaboration with the Haematology Clinical Trais Unit at St George Hospital, these innovations are currently being evaluated for their potential in therapeutic development and clinical implementation. Besides preclinical studies and clinical trials of our discoveries, we also focus on clinical trials of new anticoagulants and immune-induced thrombocytopenia (ITP) treatment with the goal to gain new knowledge, improve diagnosis, and treatment for venous thromboembolism and ITP.
Our goals
Central to our research is to improve the cardiovascular outcomes for patients at risk of thrombosis, both arterial and venous, and bleeding complications. Through a combination of basic science research and clinical studies, we aim to:
- Advance understanding of thrombotic and haemostatic (bleeding) mechanisms
- Develop novel anti-thrombotic therapies with reduced risk of bleeding
- Identify biomarkers for thrombotic risk and resistance to current treatments
- Create innovative bioassays to improve diagnosis and enable personalised medicine听
Research strengths
Our team brings together researchers and collaborators with diverse and complementary expertise across clinical medicine, biochemistry, proteomics, cell biology, chemistry, biophysics, computational biology, animal models, clinical trials, and drug discovery, development and commercialisation. This multidisciplinary strength enables a comprehensive approach to investigating complex questions in haematology and cardiovascular diseases. Through this integrated expertise, we are uncovering previously unrecognised mechanisms underlying thrombosis, haemostasis, and inflammation, and are actively developing innovative solutions to address unmet clinical needs.
Our results
Our findings are published in top-tier biomedical journals including Blood, Circulation Research, Nature Communications, Lancet, New England Medical Journal and Journal of American Medical Association (JAMA). Some highlights of our recent work include:
-
Chong BH, 2025,'Disrupting HIT immune complexes as a new treatment for HIT', Blood, 145, pp. 2939 - 2941,
-
Dupuy A; Aponte-Santamaria C; Yeheskel A; Hortle E; Oehlers SH; Grater F; Hogg PJ; Passam FH; Chiu J, 2023, 'Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement under Flow',鈥疌irculation Research, 132, pp. E151 - E168,
-
Zheng SS; Ahmadi Z; Leung HHL; Wong R; Yan F; Perdomo JS; Chong BH, 2022, 'Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia', Haematologica, 107, pp. 2195 - 2205,
-
Leung HHL; Perdomo J; Ahmadi Z; Zheng SS; Rashid FN; Enjeti A; Ting SB; Chong JJH; Chong BH, 2022,'NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia', Nature Communications, 13,
Perdomo J; Leung HHL; Ahmadi Z; Yan F; Chong JJH; Passam FH; Chong BH, 2019,'Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia', Nature Communications, 10, pp. 1322,
Our experts
Key collaborators
- National collaborators
- International collaborators
- 听
- , Director of Clinical Haematology, Massachusetts General Hospital, Harvard Medical School, Boston, USA听
- , Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
- , Perelman School of Medicine at the鈥疷niversity of Pennsylvania, USA
- , Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
- , Weill Cornell Medical College, USA听
- Professor Andreas Greinacher, Head of Department of Transfusion Medicine, University of Greifswald, Germany听