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Mr Matt Paradise

Mr Matt Paradise

Visiting Fellow
Medicine & Health
Centre for Healthy Brain Ageing

Matt is an Old Age Psychiatrist and Researcher within the Neuroimaging and Neuropsychiatry Groups at CHeBA, and trained both in the UK and Australia. He is the recipient of the Dean鈥檚 Award for Outstanding PhD Theses, having recently completed his PhD in vascular cognitive impairment and neuroimaging with Professor Perminder Sachdev AM, Co-Director of CHeBA. He has also gained a Masters of Psychiatric Research from University College London (UCL). He has published over 20 papers in high impact journals, with a h-index of 13 (Aug 2022). 听 听

Matt鈥檚 dual role as clinician and researcher has developed his unique understanding of the dementia experience. His research interests include late-life depression, mild-cognitive impairment, cerebrovascular imaging, dementia service development and dementia risk-reduction. He works as a Senior Research Fellow and clinical advisor with the Memory Clinic Initiative of the Australian Dementia Network (ADNet). 听

In 2016, he received a Dementia Centre for Research Collaboration grant to develop a novel MRI-based cerebrovascular pathology index which he hopes will be used to improve diagnostic procedures for clinicians, researchers and the wider community. In 2018, Matt was the inaugural recipient of the Josh Woolfson Memorial Scholarship which supports research looking at modifiable risk factors for Alzheimer鈥檚 disease to identify and target at-risk groups and individuals and develop intervention strategies for risk reduction. 听

Matt is a strong advocate for older people and works clinically as a Senior Staff Specialist at Concord Hospital and as a Senior VMO in Coffs Harbour.听

  • Book Chapters | 2015
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood, and sleep', in Handbook of Depression in Alzheimer S Disease, pp. 355 - 366,
    Book Chapters | 2015
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood, and sleep', in Handbook of Depression in Alzheimer's Disease, pp. 355 - 366,
  • Journal articles | 2025
    Mehrani I; Paradise M; Low LF; Kurrle S; Arsenova V; Jahn G; Fyfe K; Michaelian JC; Salmon K; Alty J; Naismith SL; Sachdev PS, 2025, 'Developing, implementing, and evaluating the first national Memory and Cognition Clinic Guidelines in Australia', Alzheimer S and Dementia Translational Research and Clinical Interventions, 11,
    Journal articles | 2023
    Duperron MG; Knol MJ; Le Grand Q; Evans TE; Mishra A; Tsuchida A; Roshchupkin G; Konuma T; Tr茅gou毛t DA; Romero JR; Frenzel S; Luciano M; Hofer E; Bourgey M; Dueker ND; Delgado P; Hilal S; Tankard RM; Dubost F; Shin J; Saba Y; Armstrong NJ; Bordes C; Bastin ME; Beiser A; Brodaty H; B眉low R; Carrera C; Chen C; Cheng CY; Deary IJ; Gampawar PG; Himali JJ; Jiang J; Kawaguchi T; Li S; Macalli M; Marquis P; Morris Z; Mu帽oz Maniega S; Miyamoto S; Okawa M; Paradise M; Parva P; Rundek T; Sargurupremraj M; Schilling S; Setoh K; Soukarieh O; Tabara Y; Teumer A; Thalamuthu A; Trollor JN; Vald茅s Hern谩ndez MC; Vernooij MW; V枚lker U; Wittfeld K; Wong TY; Wright MJ; Zhang J; Zhao W; Zhu YC; Schmidt H; Sachdev PS; Wen W; Yoshida K; Joutel A; Satizabal CL; Sacco RL; Bourque G; Lathrop M; Paus T; Fernandez-Cadenas I; Yang Q; Mazoyer B; Boutinaud P; Okada Y; Grabe HJ; Mather KA; Schmidt R; Joliot M; Ikram MA; Matsuda F; Tzourio C; Wardlaw JM; Seshadri S; Adams HHH; Debette S, 2023, 'Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease', Nature Medicine, 29, pp. 950 - 962,
    Journal articles | 2021
    Debette S; Duperron M-G; Knol M; Grand QL; Evans T; Mishra A; Roshchupkin G; Konuma T; Tr茅gou毛t D-A; Romero J; Frenzel S; Luciano M; Hofer E; Bourgey M; Dueker N; Delgado P; Hilal S; Tankard R; Dubost F; Shin J; Saba Y; Armstrong N; Bordes C; Bastin M; Beiser A; Brodaty H; B眉low R; Carrera C; Chen C; Cheng C-Y; Deary I; Gampawar P; Himali J; Jiang J; Li S; Macalli M; Marquis P; Morris Z; Maniega SM; Paradise M; Pedram P; Rundek T; Sargurupremraj M; Schilling S; Soukarieh OTBC; Teumer A; Thalamuthu A; Trollor J; Tsuchida A; Hern谩ndez MV; Vernooij M; V枚lker U; Wittfeld K; Wong TY; Wright M; Yang Q; Zhang J; Zhao W; Zhu Y; Schmidt H; Sachdev P; Wen W; JOUTEL A; Satizabal C; Sacco R; Bourque G; Lathrop M; Paus T; Fernandez-Cadenas I; Mazoyer B; Okada Y; Grabe H; Mather K; Schmidt R; Ikram A; Tzourio C; Wardlaw J; Seshadri S; Adams H, 2021, 'Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease', ,
    Journal articles | 2021
    Paradise M; Crawford JD; Lam BCP; Wen W; Kochan NA; Makkar S; Dawes L; Trollor J; Draper B; Brodaty H; Sachdev PS, 2021, 'Association of Dilated Perivascular Spaces With Cognitive Decline and Incident Dementia', Neurology, 96, pp. E1501 - E1511,
    Journal articles | 2020
    Liu Y; Chan DKY; Thalamuthu A; Wen W; Jiang J; Paradise M; Lee T; Crawford J; Wai Kin Wong M; Hua Xu Y; Poljak A; Pickford R; Sachdev PS; Braidy N; Xu Y-H, 2020, 'Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia', Computational and Structural Biotechnology Journal, 18, pp. 1613 - 1624,
    Journal articles | 2019
    Paradise DM, 2019, 'Commentary on: Mechanisms Linking White Matter Lesions, Tract Integrity and Depression in Alzheimer's Disease', American Journal of Geriatric Psychiatry, 27, pp. 960 - 962,
    Journal articles | 2019
    Paradise M; Sachdev PS, 2019, 'Vascular cognitive disorders', Seminars in Neurology, 39, pp. 241 - 250,
    Journal articles | 2019
    Paradise M; Seruga A; Crawford JD; Chaganti J; Thalamuthu A; Kochan NA; Brodaty H; Wen W; Sachdev PS, 2019, 'The relationship of cerebral microbleeds to cognition and incident dementia in non-demented older individuals', Brain Imaging and Behavior, 13, pp. 750 - 761,
    Journal articles | 2019
    Paradise MB; Beaudoin MS; Dawes L; Crawford JD; Wen W; Brodaty H; Sachdev PS, 2019, 'Development and validation of a rating scale for perivascular spaces on 3T MRI', Journal of the Neurological Sciences, 409, pp. 116621 - 116621,
    Journal articles | 2018
    Jiang J; Paradise M; Liu T; Armstrong NJ; Zhu W; Kochan N; Brodaty H; Sachdev PS; Wen W, 2018, 'The association of regional white matter lesions with cognition in a community-based cohort of older individuals', NeuroImage: Clinical, 19, pp. 14 - 21,
    Journal articles | 2018
    Paradise M; Shepherd CE; Wen W; Sachdev PS, 2018, 'Neuroimaging and neuropathology indices of cerebrovascular disease burden: A systematic review', Neurology, 91, pp. 310 - 320,
    Journal articles | 2015
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood, and sleep', Advances in Alzheimer S Disease, 4, pp. 355 - 365,
    Journal articles | 2015
    Diamond K; Mowszowski L; Cockayne N; Norrie L; Paradise M; Hermens DF; Lewis SJG; Hickie IB; Naismith SL, 2015, 'Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep', Journal of Alzheimer S Disease JAD, 44, pp. 1181 - 1191,
    Journal articles | 2015
    Jayaweera HK; Hickie IB; Duffy SL; Hermens DF; Mowszowski L; Diamond K; Terpening Z; Paradise M; Lewis SJG; Lagopoulos J; Naismith SL, 2015, 'Mild Cognitive Impairment Subtypes in Older People with Depressive Symptoms: Relationship with Clinical Variables and Hippocampal Change', Journal of Geriatric Psychiatry and Neurology, 28, pp. 174 - 183,
    Journal articles | 2015
    Paradise M; Mccade D; Hickie IB; Diamond K; Lewis SJG; Naismith SL, 2015, 'Caregiver burden in mild cognitive impairment', Aging and Mental Health, 19, pp. 72 - 78,
    Journal articles | 2014
    Duffy SL; Paradise M; Hickie IB; Lewis SJG; Naismith SL; Lagopoulos J, 2014, 'Cognitive impairment with and without depression history: An analysis of white matter microstructure', Journal of Psychiatry and Neuroscience, 39, pp. 135 - 143,
    Journal articles | 2014
    Elcombe EL; Lagopoulos J; Mowszowski L; Diamond K; Paradise M; Hickie IB; Lewis SJG; Naismith SL, 2014, 'Clinical and cognitive correlates of structural hippocampal change in "at-risk" older adults', Journal of Geriatric Psychiatry and Neurology, 27, pp. 67 - 76,
    Journal articles | 2012
    Mowszowski L; Ward PB; Diamond K; Paradise M; Kaur M; Lewis SJG; Hickie I; Hermens DF; Naismith S, 2012, 'Reduced temporal mismatch negativity in late-life depression: An event-related potential index of cognitive deficit and functional disability?', Journal of Affective Disorders, 138, pp. 71 - 78,
    Journal articles | 2012
    Paradise MB; Naismith SL; Davenport TA; Hickie IB; Glozier NS, 2012, 'The impact of gender on early ill-health retirement in people with heart disease and depression', Australian and New Zealand Journal of Psychiatry, 46, pp. 249 - 256,
    Journal articles | 2012
    Paradise MB; Naismith SL; Norrie LM; Graeber MB; Hickie IB, 2012, 'The role of glia in late-life depression', International Psychogeriatrics, 24, pp. 1878 - 1890,
    Journal articles | 2011
    Paradise MB; Glozier NS; Naismith SL; Davenport TA; Hickie IB, 2011, 'Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: A cross-sectional study', BMC Psychiatry, 11,
    Journal articles | 2009
    Paradise M; Cooper C; Livingston G, 2009, 'Systematic review of the effect of education on survival in Alzheimer's disease', International Psychogeriatrics, 21, pp. 25 - 32,
    Journal articles | 2009
    Paradise M; Walker Z; Cooper C; Blizard R; Regan C; Katona C; Livingston G, 2009, 'Prediction of survival in Alzheimer's disease - The LASER-AD longitudinal study', International Journal of Geriatric Psychiatry, 24, pp. 739 - 747,
    Journal articles | 2008
    Leerkes EM; Paradise M; O'Brien M; Calkins SD; Lange G, 2008, 'Emotion and cognition processes in preschool children', MERRILL-PALMER QUARTERLY-JOURNAL OF DEVELOPMENTAL PSYCHOLOGY, 54, pp. 102 - 124,
  • Preprints | 2021
    Debette S; Duperron M-G; Knol M; Grand QL; Evans T; Mishra A; Roshchupkin G; Konuma T; Tr茅gou毛t D-A; Romero J; Frenzel S; Luciano M; Hofer E; Bourgey M; Dueker N; Delgado P; Hilal S; Tankard R; Dubost F; Shin J; Saba Y; Armstrong N; Bordes C; Bastin M; Beiser A; Brodaty H; B眉low R; Carrera C; Chen C; Cheng C-Y; Deary I; Gampawar P; Himali J; Jiang J; Li S; Macalli M; Marquis P; Morris Z; Maniega SM; Paradise M; Pedram P; Rundek T; Sargurupremraj M; Schilling S; Soukarieh OTBC; Teumer A; Thalamuthu A; Trollor J; Tsuchida A; Hern谩ndez MV; Vernooij M; V枚lker U; Wittfeld K; Wong TY; Wright M; Yang Q; Zhang J; Zhao W; Zhu Y; Schmidt H; Sachdev P; Wen W; JOUTEL A; Satizabal C; Sacco R; Bourque G; Lathrop M; Paus T; Fernandez-Cadenas I; Mazoyer B; Okada Y; Grabe H; Mather K; Schmidt R; Ikram A; Tzourio C; Wardlaw J; Seshadri S; Adams H, 2021, Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease,
    Conference Abstracts | 2019
    Paradise MB; Wen W; Sachdev PS, 2019, 'Perivascular spaces are associated with longitudinal cognitive decline and incident dementia in a healthy older cohort [Poster Abstract P3-311]', in Alzheimer's & Dementia, Elsevier BV, Los Angeles, CA, USA, Vol. 15, pp. P1410 - P1411, presented at Alzheimer's Association International Conference (AAIC) 2019, Los Angeles, CA, USA, 14 July 2019 - 16 July 2019,