Current
Vascular Cognitive Impairment and Dementia (VCID) study
Analysis of blood, cerebrospinal fluid, brain scans and retinal images.
Image: Roman Zayets/Shutterstock
This project aims to develop novel imaging biomarkers of early cerebrovascular alterations in VCI, and examine how they relate to brain vascular lesions, cognition (including dementia), blood biomarkers of vascular disease, and vascular risk factors.聽
Study objectives:聽
- To examine the ability of novel imaging biomarkers (cerebral blood flow (CBF), blood-brain barrier (BBB) permeability, and cerebrovascular reactivity (CVR) to discriminate between diagnostic groups (healthy vs. diseased (i.e., vascular mild cognitive impairment and Vascular Dementia).聽
- To examine the relationship of CBF, BBB permeability, and CVR with small vessel disease lesions on MRI (white matter hyperintensities, cerebral microbleeds, dilated perivascular spaces, lacunes) and their progression.
- To examine the relationship of global and regional CBF, BBB permeability, and CVR with neuropsychological test scores.聽
The VCI study is actively recruiting participants (aged 50-80 years old) who:
- Have Vascular Dementia,
- Have Vascular Mild Cognitive Impairment, or
- Are healthy without cognitive impairment.
Research personnel
- Professor Perminder Sachdev - Project leader
- Dr Russell Chander - Study Coordinator
- Dr Jiyang Jiang
- Dr Vibeke Catts
- Dr Claudia Hillenbrand
- Dr Karen Mather
- Dr Anne Poljak
- Dr Satoshi Hosoki
- Associate Professor Wei Wen
- Dr Anbupalam Thalamuthu
- Dr Matthew Paradise
- Dr Sumangali Gobhidharan
- Dr Adith Mohan
- Dr Ralf Loeffler
- Dr Tharusha Jayasena
Project status
Project group
Vascular Contributions to Dementia- Centre of Research Excellence (VCD-CRE)
Related research group
Contact
If you鈥檙e interested in participating in this study, please contact the research team at聽cheba.vasmarker@unsw.edu.au