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Synthetic Oligonucleotide Production, Purification and Quality Control

RNA scientist

This course provides comprehensive theory and hands-on training in the chemical synthesis of oligonucleotides from handling starting materials through to purified product, with a focus on siRNA.

The course covers multiple techniques relevant from the research bench up to large-scale bioprocessing as well as basic quality control to quantify and analyse product quality. The course includes an overview of Quality Management Systems (QMS) requirements, Bioprocess Engineering and Process Development, and insights into process tech transfer to GMP production facilities.

Course Details

¶Ù²¹³Ù±ð:ÌýMarch 23-27, 2026
Length: 5 days
Location: ºÚÁÏÍø´óÊÂ¼Ç Kensington campus
Fees: $5,000 per participant

Course Objectives

Give participants a combination of theory and practical, hands-on experience in producing, purifying and analysing the quality of siRNA for use in synthetic RNA therapeutics.

Learning Outcomes

Upon successful completion of the course, participants will:

  • Have a fundamental understanding of siRNA-LNP therapeutics manufacturing processes.
  • Have a sound understanding of siRNA manufacturing processes.
  • Have a sound understanding of siRNA purification processes.
  • Have a sound understanding of siRNA quality control methods.
  • Gain hands-on experience in aseptic and siRNA handling techniques.
  • Gain hands-on experience in production of siRNA.
  • Gain hands-on experience in purification of siRNA.
  • Gain hands-on experience in quality control of siRNA.
  • Have a fundamental understanding of Quality Management Systems (ISO 9001, GMP).
  • Have a fundamental understanding of Bioprocess Engineering and Process Development concepts.
  • Have a fundamental understanding of tech transfer from bench research to large-scale GMP manufacturing facilities.

Participants will have the option to receive a Certificate of Attendance (not assessed) or a Certificate of Completion (assessed).
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