黑料网大事记

ICC-Dementia

A working group of the International Consortium of Centenarian (ICC) studies examining risk and protective factors for dementia across global centenarian cohorts.

Personalise

About ICC-Dementia

Ageing and dementia are inextricably linked, with the risk of dementia rising rapidly after 65 years of age. However, not all people develop dementia and some are able to postpone its development until extremely late in life. Estimates for dementia prevalence in the 鈥渙ldest-old鈥 age group, variously described as comprising nonagenarians, centenarians, semi-super centenarians and super centenarians vary widely. Consistent risk and protective factors for dementia at the extreme end of life have yet to be identified.

The International Centenarian Consortium of Dementia (ICC-Dementia) is interested in studying those at the extreme end of life. ICC-Dementia was formulated in 2012 and is comprised of eighteen different centenarian and near-centenarian studies from Asia, Europe, the Americas, and Oceania. ICC-Dementia seeks to harmonise data from these studies internationally to describe the cognitive and functional profiles of the exceptionally old individuals. The bringing together of such diverse ethnoracial and sociocultural studies allows us to explore systematically the factors for dementia and longevity, as well as provides real-life models of healthy brain ageing. We anticipate that this will provide insights into the underlying mechanisms of dementia and point to possible ways of escaping or delaying the onset of common dementias until extremely late in life
Will we all get dementia if we live long enough? ICC-Dementia may have the answer.
CHeBA Consortia

Aims and objectives

  1. To enable the comparison of data collected by worldwide centenarian studies of brain ageing.
  2. To validate the diagnosis of dementia by applying common diagnostic criteria and examining the rate of cognitive decline in those cohorts in which longitudinal data are available. Further validation will be carried out using neuroimaging and neuropathology.
  3. To examine and compare cross-nationally risk and protective factors for dementia at the extreme end of life.
  4. To identify factors that predict successful brain ageing into the 11th decade of life that are robust across cohorts. This will spearhead an international effort to promote successful brain ageing.

Members

Membership criteria

Studies are eligible to participate in ICC-Dementia if they meet the following criteria:

  • The main focus is on individuals aged 鈮95 years
  • Have a minimum sample of 80 individuals
  • Assessment includes measures of cognitive function and activities of daily living
  • Informed consent forms allow for de-identified data sharing with academic partners.

All participating studies have the opportunity to participate in the analyses and to propose specific projects and papers.

Studies from South America and Africa are particularly encouraged to apply.

ICC-Dementia Scientific Steering Committee

Each study is invited to provide one member for the Steering Committee, which leads the scientific agenda of the consortium and provides governance.

Member Study
Nir Barzilai Longevity Gene Project (LGP)
Carol Brayne Cognitive Function and Ageing Study (CFAS)
Henry Brodaty Sydney Centenarian Study (SCS)
Karen Cheung Hong Kong Centenarian Study (HKCS)
Maria Corrada 90+ Study (90+)
Yasuyuki Gondo Tokyo Centenarian Study (TCS)
Bo Hagberg Swedish Centenarian Study (SwCS)
Henne Holstege The 100-plus Study (100+)
Daniela Jopp Fordham Centenarian Study (FH)
2nd Heidelberg Centenarian Study (HD100-II)
Claudia Kawas 90+ Study (90+)
Jeffery Kaye Oregon Brain Aging Study (OBAS)
Yvonne Leung (Secretariat) Sydney Centenarian Study (SCS)
Ugo Lucca Monzino 80+ Study (M80+)
Gabriella Marcon Centenarians at Trieste (CaT)
Peter Martin Georgia Centenarian Study (GCS)
Lennie Poon Georgia Centenarian Study (GCS)
脫scar Ribeiro PT100 Study
Perminder Sachdev Sydney Centenarian Study (SCS)
Ingmar Skoog Gothenburg Centenarian Study (Go95+)
Jan Szewieczek Polish Centenarian Study (PCS)

Member Studies

  • 90+ Study (90+)
  • The 100-plus Study (100+)
  • Centenarians at Trieste (CaT)
  • Cognitive Function and Ageing Study (CFAS)
  • Fordham Centenarian Study (FH)
  • Georgia Centenarian Study (GCS)
  • Gothenburg Centenarian Study (Go95+)
  • 2nd Heidelberg Centenarian Study (HD100-II)
  • Hong Kong Centenarian Study (HKCS)
  • Longevity Gene Project (LGP)
  • Monzino 80+ Study (M80+)
  • Oporto Centenarian Study (PT100)
  • Oregon Brain Aging Study (OBAS)
  • Polish Centenarian Study (PCS)
  • Swedish Centenarian Study (SwCS)
  • Sydney Centenarian Study (SCS)
  • Tokyo Centenarian Study (TCS)

Expressed Interest From

  • New England Centenarian Study (NECS)
  • Five Country Oldest Old Project (5COOP)
  • Spanish Centenarian Study (SpCS)
  • Kurihara Project, Japan
  • The Dynamic Analyses to Optimise Ageing project (DYNOPTA)

Articles

Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Vi帽a J, Perls T, Sachdev PS. (2016).聽.聽BMC Neurol., 16: 52.

Conference Presentations

Daly, C. (2016). ICC - Dementia: International prevalence of dementia, cognitive impairment and functional dependence in centenarians.聽ICC Porto Conference.

ICC-Dementia Projects

  1. Determine the prevalence of dementia in centenarians from diverse ethnoracial and cultural groups, using common diagnostic criteria.
  2. Investigate the reasons why some individuals achieve an extreme old age without showing cognitive decline.
  3. Examine the biomarkers of dementia and cognitive decline in centenarians.
  4. Identify the risk and protective factors, including contextual factors, for dementia and healthy brain ageing in centenarians.

Research proposal

CC-Dementia welcomes research proposals from member studies and from outside investigators wishing to utilise the wealth and diversity of data held by the ICC-Dementia cohorts.

All proposals will be reviewed by the ICC-Dementia Research Steering Committee, and should be submitted using the PDF form below.

Download the ICC-Dementia Research Proposal Form

Please note that ICC-Dementia member studies are not committed to providing data for all projects, and elect to participate on a project-by-project basis.

Any publication arising from the use of cohort data requires

  1. Consultation with the study leader; and
  2. Inclusion of the study leader and other members as co-authors.

Proposals from outside investigators require sponsorship by a lead investigator of an ICC-Dementia member study.

Details of the member studies can be found on the聽ICC-Dementia Studies page, and it may be appropriate to seek sponsorship from the leader of a study that has investigated similar issues or holds particularly relevant data.

Contact

Perminder Sachdev
贰听p.sachdev@unsw.edu.au
Co-Director, CHeBA (Centre for Healthy Brain Ageing), 黑料网大事记 Medicine