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STROKOG

Consortium of post-stroke/TIA or high vascular risk studies from around the world. Originally established in 2016, it was the first international effort to harmonise work on post-stroke dementia.

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STROKOG is a consortium of post-stroke/TIA or high vascular risk studies from around the worl

About STROKOG

STROKOG is a consortium of post-stroke/TIA or high vascular risk studies from around the world. STROKOG aims to harmonise data across our international member studies; to conduct joint analyses that explore questions in relation to vascular cognitive impairment and dementia (VCID), which represent a major health care burden on our society with projections to grow in the future.

STROKOG aims to increase awareness of cognitive deficits in relation to stroke and other cerebrovascular disease. We anticipate that the findings of STROKOG will help guide and optimize preventative strategies and health policy, both in Australia and internationally.

The consortium is expanding from 2022 to include, in addition to studies with stroke/TIA patients, studies with high vascular risk patients or intervention studies that aim to reduce the impact of cerebrovascular disease.

Please see belowÌýfor:

  • Membership criteria
  • Research studies
  • Research propssals

ÌýSTROKOG currently includesÌý41 studiesÌýfrom 20 countries and 5 continents. We encourage qualified researchers to propose research projects using STROKOG data. Please refer to theÌýresearch proposalsÌýbelow for more information.
CHeBA Consortia

Consortium

Membership criteria

The membership criteria for STROKOG have been revised in 2023. Studies with the following features are invited to participate:

  • Studies of stroke, TIA, or high vascular risk patients with cognitive decline or impairment as primary or secondary outcomes (i.e., cognitive assessments were conducted, even if brief); or
  • Intervention studies with the objective of reducing the impact of CVD, with cognition as primary or secondary outcome.


Membership will be officially ratified by study leaders signing a memorandum of understanding that entails willingness to:

  • Willing to share data (on a per-project basis) at either the level of individuals or in summary form, and/or provide the results of in-house analyses performed using STROKOG protocols (although members are not obliged to share data until they are ready),
  • Willing to share images with collaborators, within legislative and ethical constraints of the study,
  • Willing to contribute intellectually to meet the objectives of STROKOG,
  • Committed to the ethical principles of the consortium, and
  • Willing to contribute to the training and mentorship of junior researcher within their own groups or in STROKOG generally.
  • The willingness to share biospecimens collected by the studies for research purposes is an option that may be considered.

Interested parties please contact the STROKOG Coordinator about joining STROKOG.

Jessica Lo |Ìýjessica.lo@unsw.edu.au.

STROKOG Scientific Steering Committee

The STROKOG Scientific Steering Committee is formed to lead the scientific agenda of the consortium and provide ongoing support and governance. It comprises of one representative from each of the contributing studies, generally the lead investigator or a delegate.

Member Study, Country
Dr Rufus Akinyemi Cognitive Function After Stroke Nigeria (CogFAST-Nigeria), Nigeria
Professor Hee-Joon Bae Bundang VCI cohort (Bundang VCI), Korea
Professor Philip Bath Prevention Of Decline in Cognition After Stroke Trial (PODCAST), UK
Professor Régis Bordet Clinical Biological and Pharmacological Factors Influencing Stroke Outcome (BIOSTROKE)ÌýandÌý, France
Dr Amy Brodtmann Cognition and Neocortical Volume After Stroke (CANVAS), Australia
Professor Christopher Chen Cognitive Outcome After Stroke (COAST), Singapore
Dr Chih-Ping Chung Stroke Registry Study of Taipei Veterans General Hospital (SRS@TVGH), Taiwan Ìý
Dr Charlotte Cordonnier Prognosis of Intracerebral Haemorrhage (PITCH), France
Dr Paul de Kort Prediction of cognitive recovery after stroke (PROCRAS), Netherlands
Dr David Desmond Epidemiologic Study of the Risk of Dementia After Stroke, USA
Professor Martin Dichgans Determinants of Dementia After Stroke (DEDEMAS), Germany
Dr Abdel Douiri South London Stroke Register (SLSR), UK
Professor Olivier Godefroy Groupe de Réflexion pour l'Evaluation COGnitive VASCulaire study (GRECOG-VASC), France
Dr Michael Hoffmann Durban Stroke Data Bank (DSDB), South Africa
Dr Masafumi Ihara Risk Assessment of Cnm-positive Streptococcus Mtuans in Stroke Survivors (RAMESSES), Japan Ìý
Dr Hanna Jokinen Helsinki Stroke Aging Memory (SAM), Finland
Professor Raj Kalaria Cognitive Function After Stroke (CogFAST), UK
Dr Nagaendran Kandiah National Neuroscience Institute (Post Stroke Cognitive Impairment) Study, Singapore
Professor Frini Karayanidis Systems of Care in Minor Stroke & TIA: Cognition (INSIST-COG), Australia
Dr Aleksandra Klimkowicz-Mrowiec Cracow Stroke DatabaseÌýandÌýPRospective Observational POLIsh Study (PROPOLIS), Poland
Dr Sebestian Köhler Cognition and Affect after Stroke: Prospective Evaluation of Risks (CASPER)ÌýandÌýMaastricht Cognitive Disorders After Stroke (CODAS), The Netherlands
Dr Gary Lau The HKU Stroke Cohort, Hong Kong
Professor Byung-Chul Lee Korean-Vascular Cognitive Impairment Harmonization Standards Study (K-VCIHS), Korea
Dr Thomas Linden Göteborg 70+ Stroke Study, Sweden
Professor Hugh Stephen Markus St George's Cognition and Neuroimaging in Stroke (SCANS), UK andÌýApathy and Outcome after Stroke Study, UKÌý
Dr Javier Marta-Moreno ICTUS Cog Aragón (ICTUS), SpainÌý
Professor Vincent Mok Stroke Registry Investigating Cognitive Decline (STRIDE), Hong Kong
Dr Akin OjagemiÌý Delirium and Risk of Vascular dementia after a Stroke (DRIVERS), Nigeria
Professor Michael O'Sullivan White Matter Connections and Memory: The STRATEGIC Study, UK
Dr Behnam Sabayan Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), The Netherlands, Scotland, Ireland
Professor Perminder Sachdev Sydney Stroke Study (SSS), Australia
Professor Velandai Srikanth North East Melbourne Stroke Incidence Study (NEMESIS), Australia
Professor Latchezar Traykov Bulgarian Post-stroke StudyÌýandÌýSubcortical small vessel disease - Bulgarian cohort, Bulgaria
Professor Joanna Wardlaw Mild Stroke Study II (MSS-II), UK
Professor Kyung-Ho Yu Hallym VCI, Korea
Professor Qun Xu Renji CSVD Cohort Study (RCCS), China

Member studies

Study Country Key reference(s)
Apathy and Outcome after Stroke Study UK Pallucca C et al. (2024)
Bundang VCI cohort (Bundang-VCI) Korea Lim et al. (2014)
Bulgarian Post-Stroke Study Bulgaria Mehrabian et al. (2015)
Clinical Biological and Pharmacological Factors Influencing Stroke Outcome (BIOSTROKE) France Ducroquet et al. (2013)
Cognition and Affect after Stroke: Prospective Evaluation of Risks (CASPER) Netherlands Douven et al. (2016)
Cognition and Neocortical Volume After Stroke (CANVAS) Australia Brodtmann et al. (2014)
Cognitive Function After Stroke (CogFAST-UK) UK Allan et al. (2011)
Cognitive Function After Stroke Nigeria (CogFAST-Nigeria) Nigeria Akinyemi et al. (2014)
Cognitive Outcome After Stroke (COAST) Singapore Dong et al. (2012)
Cracow Stroke Database (Cracow) Poland Klimkowicz et al. (2004; 2006)
Cognitive Outcome After Stroke (COAST) Singapore Dong et al. (2012)
Delirium and Risk of Vascular dementia after a Stroke (DRIVERS) Nigeria Ojagbemi et al. (2017)
Determinants of Dementia After Stroke (DEDEMAS) Germany Wollenweber et al. (2013)
Durban Stroke Data Bank (DSDB) South Africa Hoffmann (1998; 2001)
Epidemiologic study of the risk of dementia after stroke (Epi USA) USA Desmond et al. (2000, 2002)
Göteborg 70+ Stroke Study (Göteborg Neuro70+) Sweden Linden et al. (2004; 2007)
Groupe de Réflexion pour l'Evaluation COGnitive VASCulaire study (GRECOG-VASC)ÌýIDEA3 (follow up) France Godefroy et al. (2012)
Hallym VCI Korea KH Yu et al. (2013)
Helsinki Stroke Aging Memory (SAM) Finland Jokinen et al. (2015); Oksala (2009)
ICTUS Cog Aragón (ICTUS) Spain Javier Marta Moreno (2021)
Imperial Post-stroke Aphasia Recovery Study UK StefaniakÌýet al. (2002)
Maastricht Cognitive Disorders After Stroke (CODAS) Netherlands Rasquin et al. (2005)
Mild Stroke Study II (MSS–II) UK Heye et al. (2015; 2016)Valdes Hernanadez et al. (2015)
Korean-Vascular Cognitive Impairment Harmonization Standards Study (K-VCIHS) Korea Yu et al. (2013)
North East Melbourne Stroke Incidence Study (NEMESIS) Australia Srikanth et al. (2003; 2004; 2006)
National Neuroscience Institute study (NNI Singapore) Singapore Kandiah et al. (2011; 2014, 2016)
Prediction of cognitive recovery after stroke (PROCRAS) Netherlands Aben et al. 2018
Prevention Of Decline in Cognition After Stroke Trial (PODCAST) UK Bath et al (2017)
Prognosis of Intracerebral Haemorrhage (PITCH) France Cordonnier et al. (2010); Moulin et al. (2016)
PRospective Observational POLIsh Study (PROPOLIS) Poland Pasińska et al. 2019
Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)Ìý Scotland, Ireland, Netherlands Shepherd et al. (2002)
Risk Assessment of Cnm-positive Streptococcus Mtuans in Stroke Survivors (RAMESSES) Japan Satoshi et al. (2022)
Renji CSVD Cohort Study (RCCS) China Cao et al. (2016); Sun et al. (2016)
South London Stroke Register (SLSR) UK Wolfe et al. (2011)
Douiri et al. (2013)
St George's Cognition and Neuroimaging in Stroke (SCANS) UK Lawrence et al. (2015)
Stroke Registry Investigating Cognitive Decline (STRIDE) Hong Kong Yang et al. (2015); Liu et al. (2015); Wang et al. (2015a, 2015b); Mok et al. (2016)
Stroke Registry Study of Taipei Veterans General Hospital (SRS@TVGH) Taiwan Lee YC et al. (2020)
Study of Factors Influencing Post-Stroke Dementia (STROKDEM) France Ponchel et al. (2016)
Subcortical Small Vessel Disease - Bulgarian Cohort Bulgaria Latchezar TraykovÌý(2012)
Sydney Stroke Study (SSS) Australia Sachdev et al. (2004; 2014)
Systems of Care in Minor Stroke & TIA: Cognition (INSIST-COG) Australia NA
The HKU Stroke Cohort Hong Kong Lau et al. (2017)
UK NA

Member in negotiation

Study Country
Action on Secondary Prevention Interventions and Rehabilitation in Stroke study(ASPIRE-S) Ireland

Methodology paper

Sachdev PS, Lo JW, Crawford JD, et al.Ìý. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring. 2017;7:11-23. doi:10.1016/j.dadm.2016.10.006.

Research Papers

  1. Lo JW, Crawford JD, Desmond DW, et al.ÌýÌýNeurology.Ìý2019;93(24):e2257-e2271.Ìý
  2. Lo JW, Crawford JD, Samaras K, et al.Ìý.ÌýStroke. 2020;51(6):1640-1646.Ìý
  3. Tang EYH, Price CI, Robinson L, et al.Ìý.ÌýStroke. 2020;51(7):2095-2102.Ìý
  4. Lo JW, Crawford JD, Desmond DW, et al.Ìý.ÌýStroke. 2022;53(4):1318-1327.Ìý
  5. Betrouni N, Jiang J, Duering M, et al.Ìý.ÌýStroke. 2022;53:3446–3454
  6. Lo JW, Crawford JD, Desmond DW, et al.Ìý. Neurology. 2023;100(23):e2331-e2341.ÌýÌý
  7. Oestreich LKL, Lo JW, Di Biase MA, Sachdev PS, et al.ÌýÌýPsychiatry Clin Neurosci. 2023 Dec 19. doi: 10.1111/pcn.13633.
  8. Ruthmann F, Lo JW, Mendyk-Bordet AM, et al.. Journal of Affective Disorders. 2025; 369:1136-44.

List of STROKOG projects

Updated January 2025
Project Title Lead Investigator (Affiliation)
Domain-specific cognitive impairments and depression as determinants of post-stroke functional disability Hanna Jokinen (Helsinki University Hospital and University of Helsinki)
Risk factors for post-stroke depression Ben Lam (CHeBA, ºÚÁÏÍø´óʼÇ)
Post-stroke neuropsychiatric symptoms: apathy and psychosis Michael Connors (CHeBA, ºÚÁÏÍø´óʼÇ)
Trajectory of post-stroke depression Lena Oestreich (University of Queensland)
A simple risk model for the prediction of post-stroke dementia Jess Lo (CHeBA, ºÚÁÏÍø´óʼÇ)
Structural and functional brain disconnections associated with psychiatric complications in stroke survivors Lena Oestreich (University of Queensland)

Research proposal

STROKOG welcomes research proposals from member studies and from other researchers wishing to utilise the wealth and diversity of data held by the STROKOG cohorts. All proposals will be reviewed by the STROKOG Scientific Steering Committee. Interested researchers should contact the STROKOG Coordinator,ÌýJess Lo, to have a preliminary discussion about the project.

Note that STROKOG member studies are not committed to provide data and they may choose to participate on a project-by-project basis. It is a requirement to include the study leader (and up to 2 study members) of the study cohort as co-authors of a publication that resulted from having included the dataset in the project.

Please also note that local IRB ethics is required and proposals from investigators who are not part of STROKOG require sponsorship or endorsement by a lead investigator of a STROKOG member study. Details of all STROKOG member studies and names of lead investigators can be found on this website. It may be appropriate to seek sponsorship from the leader of a study that has investigated similar issues or holds particularly relevant data.

On the right is a flow chart which describes the process to accessing STROKOG data for a research project.

Funding Acknowledgements

We gratefully acknowledge the following funding bodies:

  • Vincent Fairfax Family Foundation (VFFF) (2016-2021)
  • NHMRC Project Grant (2019-2021; APP1161858)
  • NHMRC Centres of Research Excellence (2021-2026; RG203943)
  • NHMRC Centres of Research Excellence (2021 – 2026; ID2006765)

Contacts

Perminder Sachdev:Ìýp.sachdev@unsw.edu.au
Co-Director, CHeBA (Centre for Healthy Brain Ageing)
ºÚÁÏÍø´óÊÂ¼Ç Medicine
ÌýÌý Ìý
Jessica Lo:Ìýjessica.lo@unsw.edu.au
Postdoc Fellow, CHeBA (Centre for Healthy Brain Ageing)
ºÚÁÏÍø´óÊÂ¼Ç Medicine